Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum.

@article{S2006ExpressionAF,
  title={Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum.},
  author={Juliana Martha S{\'a} and M{\'a}rcio Massao Yamamoto and Carmen Fern{\'a}ndez-Becerra and Mauro Ferreira de Azevedo and Janni Papakrivos and Bronwen Naud{\'e} and Thomas E Wellems and Hernando A Del Portillo},
  journal={Molecular and biochemical parasitology},
  year={2006},
  volume={150 2},
  pages={219-28}
}
Chloroquine resistance in Plasmodium vivax threatens the use of this drug as first-line treatment for millions of people infected each year worldwide. Unlike Plasmodium falciparum, in which chloroquine resistance is associated with mutations in the pfcrt gene encoding a digestive vacuole transmembrane protein, no point mutations have been associated with chloroquine resistance in the P. vivax ortholog gene, pvcrt-o (also called pvcg10). However, the question remains whether pvcrt-o can affect… CONTINUE READING

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