Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle.

@article{Schmidlin2001ExpressionAF,
  title={Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle.},
  author={Fabien Schmidlin and Silvia Amadesi and R Vidil and Marcello Trevisani and Nadine Martinet and George H. Caughey and Michele Tognetto and Giorgio Narciso Cavallesco and Christina Mapp and Pierangelo Geppetti and Nigel W Bunnett},
  journal={American journal of respiratory and critical care medicine},
  year={2001},
  volume={164 7},
  pages={1276-81}
}
Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 (PAR2) to induce alterations in contraction of airway smooth muscle that have been implicated in asthma in experimental animals. Although tryptase inhibitors are under development for treatment of asthma, little is known about the localization and function of PAR2 in human airways. We detected PAR2 expression in primary cultures of human airway smooth muscle cells using reverse transcriptase/polymerase chain reaction (RT-PCR… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…