Corpus ID: 7237395

Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation.

@article{Alexander1996ExpressionAF,
  title={Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation.},
  author={Caroline M. Alexander and Elizabeth J Hansell and Ole Behrendtsen and M L Flannery and Narendra S. Kishnani and Susan P. Hawkes and Zena Werb},
  journal={Development},
  year={1996},
  volume={122 6},
  pages={
          1723-36
        }
}
Gelatinase B, a matrix metalloproteinase (MMP) of high specific activity, is highly expressed and activated by mouse blastocysts in culture, and inhibition of this enzyme activity inhibits lysis of extracellular matrix (Behrendtsen, O., Alexander, C. M. and Werb, Z. (1992) Development 114, 447-456). Because gelatinase B expression is linked to invasive potential, we studied the expression of gelatinase B mRNA and protein in vivo, in implanting trophoblast giant cells, and found that it was… Expand
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period.
TLDR
Results suggest that MMP-2 may participate in the early phase of decidualization and neovascularization required for placentation and suggest that a fine balance between M MP-9 and TIMP-3 may regulate trophoblast invasion in the uterus. Expand
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Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-3 Are Key Regulators of Extracellular Matrix Degradation by Mouse Embryos1
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Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation
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Gelatinases A and B and tissue inhibitors of metalloproteinases 1, 2, and 3 during in vivo and in vitro decidualization of rat endometrial stromal cells.
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Endometrial mRNA levels for TIMPs 1, 2, and 3 were increased while gelatinase A levels remained unchanged and gelatinase B levels decreased during oil-induced decidualization, suggesting that PGE2 may play a role in regulating tissue remodeling during decidUALization. Expand
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TLDR
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Regional and cell-specific expression of MMPs and TIMPs closely reflects the successive stages of cerebellar development, thereby suggesting a pivotal role for ECM proteolysis in brain development and plasticity. Expand
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TLDR
The hypothesis that invading cytotrophoblasts express an unusual tissue inhibitor of metalloproteinase (TIMP) repertoire that allows them to regulate their MMP-9 proteolytic activity is tested and it is found that human cytotrophic cells express primarily TIMP-3. Expand
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TLDR
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It is suggested that, in differentiating trophoblasts, NO regulates the induction of matrix-degrading proteases required for invasion during embryo implantation. Expand
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It is demonstrated that proteinase activity in early embryos can be regulated by growth factors and cytokines during the implantation process and, in particular, the possible involvement of LIF in establishment of the correct temporal programme of proteinase expression is demonstrated. Expand
Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths.
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Observations suggest that several metalloproteinases are regulated in early development and that 92 x 10(3) Mr gelatinase, in particular, has a rate-limiting function in degradation of the maternal extracellular matrix by trophoblast cells. Expand
Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro
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Using a basement membrane invasion assay, it was found that the mutant cells, differentiated in low concentrations of serum with retinoic acid, were more invasive than their normal cell counterparts, and that this was specifically reversed by adding exogenous TIMP-1 protein. Expand
A matrix metalloproteinase expressed on the surface of invasive tumour cells
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The cloning of the complemen-tary DNA encoding a new matrix metalloproteinase with a potential transmembrane domain is reported, which may trigger invasion by tumour cells by activating pro-gelatinase A on the tumour cell surface. Expand
Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.
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Data indicate that matrix metalloproteinases are expressed in cell-type, tissue, and reproductive cycle-specific patterns, consistent with regulation by steroid hormones, and with specific roles in the complex tissue growth and remodeling processes occurring in the endometrium during the reproductive cycle. Expand
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TLDR
The results suggest that during normal development of embryonic organs the 92-kD type IV collagenase does not have a major role in basement membrane degradation, but is rather mainly used for the turnover of bone matrix, possibly as a gelatinase required for the removal of denatured collagen fragments (gelatin) generated by interstitial collagenase. Expand
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TLDR
Using in situ hybridization, it is shown that the overlapping of expression of c-ets 1 and u-PA is restricted to some maternal cell populations from the invasive front and to the endothelial cells of the endometrial vasculature. Expand
Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line.
TLDR
Overexpression of TIMP-2 markedly reduced melanoma growth in the skin of immunodeficient mice but did not prevent these highly malignant cells from spontaneously metastasizing to the lungs and lymph nodes of inoculated mice. Expand
Differential temporal and spatial expression of mRNA encoding extracellular matrix components in decidua during the peri-implantation period.
TLDR
This experiment demonstrated that the increases in uterine ECM mRNA expression were not due solely to the changing hormonal milieu of the uterus. Expand
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TLDR
Single-stranded antisense RNA probes have been used to study the expression of the metalloproteinase inhibitor TIMP during mouse embryogenesis and in adult tissues, and the high levels of TIMP RNA in the ovary are localized to cells of the corpora lutea. Expand
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