Expression and function of fibronectin binding integrins on rat mast cells.

  title={Expression and function of fibronectin binding integrins on rat mast cells.},
  author={Megumi Yasuda and Yuya Hasunuma and Hiromi Adachi and Chiyoko Sekine and T Sakanishi and Hitoshi Hashimoto and Chisei Ra and H. Yagita and Ko Okumura},
  journal={International immunology},
  volume={7 2},
Adhesion molecules of the integrin family are implicated not only in leukocyte migration but also in leukocyte activation. Here we characterize the expression and function of fibronectin receptor integrins on rat mast cells. A rat basophilic leukemia cell line (RBL-2H3) and phorbol ester-stimulated rat peritoneal mast cells adhered to fibronectin (FN), vitronectin and fibrinogen. These mast cells expressed fibronectin receptor integrins, including very late antigen (VLA)-4, VLA-5 and… CONTINUE READING


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