Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries.

@article{Cable1997ExpressionAF,
  title={Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries.},
  author={David George Cable and Timothy O'Brien and Iftikhar J. Kullo and Robert S. Schwartz and Hartzell Vernon Schaff and Vincent J. Pompili},
  journal={Cardiovascular research},
  year={1997},
  volume={35 3},
  pages={553-9}
}
OBJECTIVES Direct gene transfer of exogenous nitric oxide synthase, with the subsequent increase in nitric oxide production, could represent a potential therapeutic strategy in the treatment of vascular proliferative disorders. The goal of the present study was to determine if porcine coronary arteries could be transduced with an adenoviral vector encoding endothelial nitric oxide synthase (Ad.CMVeNOS) resulting in functional expression. METHODS AND RESULTS Segments of porcine right coronary… CONTINUE READING