Expression and function of Toll-like receptors in chicken heterophils.

  title={Expression and function of Toll-like receptors in chicken heterophils.},
  author={Michael H. Kogut and Muhammad Atif Iqbal and Haiqi He and Victoria Jane Philbin and Pete Kaiser and Adrian E Smith},
  journal={Developmental and comparative immunology},
  volume={29 9},
The heterophil is the major polymorphonuclear cell in birds with a functional capacity akin to that of the mammalian neutrophil. Herein, we demonstrate that heterophils constitutively express TLR1/6/10, TLR2 type 1, TLR2 type 2, TLR3, TLR4, TLR5, and TLR7 mRNA. Furthermore, TLR agonists, including flagellin (from Salmonella typhimurium, FGN), peptidoglycan (from Staphylococcus aureus, PGN), ultra-pure lipopolysaccharide (from Salmonella minnesota, LPS), the synthetic double stranded RNA analog… CONTINUE READING


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Global changes in gene expression by human M.H

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