Expression and function of RANK in human monocyte chemotaxis.

  title={Expression and function of RANK in human monocyte chemotaxis.},
  author={Birgit A. Mosheimer and Nicole C. Kaneider and Clemes Feistritzer and Daniel H. Sturn and Christian J Wiedermann},
  journal={Arthritis and rheumatism},
  volume={50 7},
OBJECTIVE RANKL, a member of the tumor necrosis factor superfamily, is a central regulator of osteoclast recruitment and activation. Whether RANKL affects monocyte locomotion in vitro via RANK and a possible signaling pathway were investigated. METHODS Monocytes were obtained from venous blood of healthy donors. Cell migration was studied by micropore filter assays. The signaling mechanisms required for RANKL-dependent migration were tested using signaling enzyme blockers and Western blot… CONTINUE READING