Expression and function of Flt3/flk2 in human tumor cell lines.

@article{Serve1999ExpressionAF,
  title={Expression and function of Flt3/flk2 in human tumor cell lines.},
  author={Hubert Serve and K Flesch and S Serve and Regina Fenski and Wolfgang E. Berdel},
  journal={International journal of oncology},
  year={1999},
  volume={14 4},
  pages={765-70}
}
The receptor tyrosine kinase Flt3 is expressed on the blasts of a high proportion of AML cases. We were interested in the expression and function of Flt3 on various human tumors. human tumor cell lines were tested for Flt3 expression by northern blot analysis and RT-PCR using head/neck (n=3), breast (n=4), ovarian (n=4), small cell lung (n=2), non-small cell lung (n=2), gastric (n=1), colon (n=3), pancreatic (n=1) and prostate carcinoma (n=1), choriocarcinoma (n=1), glioblastoma (n=5… CONTINUE READING