Expression and function of AGAT, GAMT and CT1 in the mammalian brain.

  title={Expression and function of AGAT, GAMT and CT1 in the mammalian brain.},
  author={Olivier Braissant and Claude Bachmann and H Andrews Henry},
  journal={Sub-cellular biochemistry},
In mammals, creatine is taken up from the diet and can be synthesized endogenously by a two-step mechanism involving the enzymes arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT). Creatine (Cr) is taken up by cells through a specific transporter, CT1. While the major part of endogenous synthesis of Cr is thought to occur in kidney, pancreas and liver, the brain widely expresses AGAT, GAMT and CT1, both during development and in adulthood. The adult central… CONTINUE READING

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