Expression and distribution of transforming growth factor-alpha within melanocytic lesions.

@article{Nanney1994ExpressionAD,
  title={Expression and distribution of transforming growth factor-alpha within melanocytic lesions.},
  author={Lillian B. Nanney and Robert J Coffey and Darrel L. Ellis},
  journal={The Journal of investigative dermatology},
  year={1994},
  volume={103 5},
  pages={707-14}
}
Stimulation of epidermal growth factor (EGF) receptor by ligands such as transforming growth factor (TGF) alpha may be associated with cell proliferation or transformation in both nevocytes and keratinocytes. Previously, EGF receptors have been identified within a variety of pigmented lesions, suggesting a possible responsiveness to ligands such as TGF alpha. In the present study, we characterize the intralesional expression and distribution of immunoreactive TGF alpha protein by avidin-biotin… CONTINUE READING