Expression and distribution of transcripts for sonic hedgehog in the early phase of fracture repair

Abstract

Localization and expression of mRNAs for sonic hedgehog (Shh) at a fracture site in the early phase postfracture were investigated by in situ hybridization and reverse transcription and polymerase chain reaction (RT-PCR). A closed fracture was made in the midshaft of the right tibia of 5-week-old ICR mice, and fractured sites were harvested prefracture… (More)
DOI: 10.1007/s00418-003-0501-z

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