Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain.

@article{Heppner2015ExpressionAD,
  title={Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain.},
  author={Kristy M. Heppner and Melissa A Kirigiti and Anna Secher and Sarah Juel Paulsen and Rikley Buckingham and Charles Pyke and Lotte Bjerre Knudsen and Niels Vrang and Kevin L. Grove},
  journal={Endocrinology},
  year={2015},
  volume={156 1},
  pages={255-67}
}
Glucagon-like peptide-1 (GLP-1) is released from endocrine L-cells lining the gut in response to food ingestion. However, GLP-1 is also produced in the nucleus of the solitary tract, where it acts as an anorectic neurotransmitter and key regulator of many autonomic and neuroendocrine functions. The expression and projections of GLP-1-producing neurons is highly conserved between rodent and primate brain, although a few key differences have been identified. The GLP-1 receptor (GLP-1R) has been… CONTINUE READING
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