Expression and distribution of cholinergic receptors in the human urothelium.

@article{Bschleipfer2007ExpressionAD,
  title={Expression and distribution of cholinergic receptors in the human urothelium.},
  author={Thomas Bschleipfer and Konstantin Schukowski and Wolfgang Weidner and Sergei A Grando and Ulrich Schwantes and Wolfgang Kummer and Katrin Susanne Lips},
  journal={Life sciences},
  year={2007},
  volume={80 24-25},
  pages={
          2303-7
        }
}
The bladder urothelium not only provides a diffusion barrier but it also serves a sensor function and releases signalling molecules that are considered to act in a paracrine and autocrine fashion, e.g. by acetylcholine. Its actions are conferred by two classes of receptors, i.e. G-protein-coupled muscarinic receptors (MR) and ionotropic nicotinic receptors (nAChR). In this study we set out to determine the expression and distribution of all MR subtypes (M1R-M5R) and nAChR alpha-subunits 7, 9… CONTINUE READING
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