Expression and distribution of S-100, CD83, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma.

@article{Xu2011ExpressionAD,
  title={Expression and distribution of S-100, CD83, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma.},
  author={Wen-can Xu and Z J Li and Yong-Ru Chen and Xi-tao Li and J Huang and Yu-Guang Li and Shen-ren Chen},
  journal={Cancer investigation},
  year={2011},
  volume={29 4},
  pages={286-92}
}
A higher expression of S-100 in tissue of thyroid papillary carcinoma (TPC) vs. thyroid follicular adenoma (TFA) (p < .001) was observed as well as a higher expression of CD83 in the peri-cancerous tissues vs. TFA (p < .001), oppositely, CD83 was negative in the cancerous net. TPC showed greater decreases in levels of CD80 and CD86 than did the TFA. These findings suggest that impaired immune function, absence of CD83-positive mature and activated dendritic cells in cancer nodules may have a… CONTINUE READING