Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck.

@article{Veit2016ExpressionAC,
  title={Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck.},
  author={Johannes Adrian Veit and Daniela Heine and Julia Thierauf and Jochen K Lennerz and Subasch Shetty and Patrick J. Schuler and Theresa L Whiteside and Dirk Beutner and M F Meyer and Inga Gr{\"u}newald and Gerd Ritter and Sacha Gnjatic and Andrew G. Sikora and Thomas K. Hoffmann and Simon Laban},
  journal={Head & neck},
  year={2016},
  volume={38 7},
  pages={1008-16}
}
BACKGROUND Adenoid cystic carcinoma (ACC) of the head and neck is a rare but highly malignant tumor. Cancer-testis antigens (CTAs) represent an immunogenic family of cancer-specific proteins and thus represent an attractive target for immunotherapy. METHODS Eighty-four cases of ACC were identified, the CTAs pan-Melanoma antigen (pan-MAGE; M3H67) and New York esophageal squamous cell carcinoma (NY-ESO-1; E978) were detected immunohistochemically (IHC) and correlated with clinical data… CONTINUE READING
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