[Expression and clinical significance of Claudin-1 and Claudin-4 in colorectal cancer tissues].

Abstract

OBJECTIVE To investigate the expression of tight junction protein Claudin-1 and Claudin-4 in colorectal cancer tissues and its clinical significance. METHODS Immunohistochemical staining detected the expression of tight junction protein Claudin-1 and Claudin-4 in 60 cases of colorectal cancer and 20 normal colorectal mucosa tissue. The clinical significance was analyzed. RESULTS The positive rates of Claudin-1 and Claudin-4 in colorectal cancer tissues were 76.6%(46/60) and 85.0%(51/60), significantly higher than 20.0% (4/20) and 30.0%(6/20) in the normal colorectal mucosa(both P<0.01). The positive rates of Claudin-1 and Claudin-4 were associated with tumor differentiation degree, lymph node metastasis and TNM staging(all P<0.05). CONCLUSIONS The high expression of the Claudin-1 and Claudin-4 may play a promoting role in colorectal cancer development and progression. Claudin-1 and Claudin-4 may become prognostic markers of colorectal cancer.

Cite this paper

@article{Wang2012ExpressionAC, title={[Expression and clinical significance of Claudin-1 and Claudin-4 in colorectal cancer tissues].}, author={Lin Wang and Shi-yong Li and P. An and Hui-yun Cai}, journal={Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery}, year={2012}, volume={15 10}, pages={1073-6} }