Expression and clinical significance of CD147 in genitourinary carcinomas.

  title={Expression and clinical significance of CD147 in genitourinary carcinomas.},
  author={Zhao-dong Han and Hui-chan He and Xue-cheng Bi and Wei-jun Qin and Qi-shan Dai and Jun Zou and Yong-kang Ye and Yu-xiang Liang and Guohua Zeng and Qian Yang and Zhi-Nan Chen and Wei-De Zhong},
  journal={The Journal of surgical research},
  volume={160 2},
BACKGROUND CD147/extracellular matrix metalloproteinase inducer (EMMPRIN) expressed by tumor cells stimulates peri-tumorous fibroblasts to produce matrix metalloproteinases (MMPs), thus contributing to tumor invasion and metastasis. To assess its suitability as a potential therapeutic target, as well as its association with the clinicopathologic features and the prognosis of patients, the expression of CD147/EMMPRIN in neoplastic tissues of the genitourinary system were analyzed. METHODS… CONTINUE READING


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