Expression and characterization of mutations in human very long-chain acyl-CoA dehydrogenase using a prokaryotic system.

Abstract

Very long-chain acyl-CoA dehydrogenase (VLCAD) catalyzes the first enzymatic step in the mitochondrial beta-oxidation of fatty acids 14-20 carbons in length. More than 100 cases of VLCAD deficiency have been reported with the disease varying from a severe, often fatal neonatal form to a mild adult-onset form. VLCAD is distinguished from matrix-soluble acyl… (More)

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@article{Goetzman2007ExpressionAC, title={Expression and characterization of mutations in human very long-chain acyl-CoA dehydrogenase using a prokaryotic system.}, author={Eric S Goetzman and Yudong Wang and Miao Tony He and A. M. M. A. Mohsen and Brittani K Ninness and Jerry Vockley}, journal={Molecular genetics and metabolism}, year={2007}, volume={91 2}, pages={138-47} }