Expression and characterization of functional dog flavin-containing monooxygenase 3.

@article{Lickteig2009ExpressionAC,
  title={Expression and characterization of functional dog flavin-containing monooxygenase 3.},
  author={Andrew J. Lickteig and Rochelle I Riley and R. Jeffrey Melton and Beverly A Reitz and H. D. Fischer and Jeffrey C. Stevens},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 10},
  pages={1987-90}
}
Mammalian flavin-containing monooxygenase (FMO) enzymes catalyze oxidation at nucleophilic, heteroatom centers and are important for drug, xenobiotic, and endogenous substrate metabolism. In human liver, human FMO3 (hFMO3) is the most abundant FMO isoform and is known to contribute to the hepatic clearance of a variety of clinical drugs. The purpose of the current study was to express and compare the dog (beagle) FMO3 (dFMO3) to hFMO3. A full-length dFMO3 cDNA was obtained from liver by reverse… CONTINUE READING