Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha.

@article{Hara2001ExpressionAC,
  title={Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha.},
  author={Shuuji Hara and Jun-ichi Hamada and Chie Kobayashi and Yukihiro Kondo and Nobumasa Imura},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={287 4},
  pages={808-13}
}
Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that regulate a number of adaptive responses to low oxygen tension. They are composed of alpha- and beta-subunits that belong to the basic helix-loop-helix-PAS superfamily. Here we examined the expression of HIF-alpha subunit proteins in the human kidney and found that, in addition to HIF-1alpha and -2alpha, HIF-3alpha was also expressed. The sequence analysis revealed that, like mouse HIF-3alpha, human HIF-3alpha has high… CONTINUE READING
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