Expression and characterization of bioactive recombinant human alpha-lactalbumin in the milk of transgenic cloned cows.

@article{Wang2008ExpressionAC,
  title={Expression and characterization of bioactive recombinant human alpha-lactalbumin in the milk of transgenic cloned cows.},
  author={Jun Wang and Pan Yang and Bikui Tang and Xiuzhu Sun and Ruihua Zhang and Chengdong Guo and Guangye Gong and Yingting Liu and Rongbai Li and Liebing Zhang and Yuesong Dai and Ning Li},
  journal={Journal of dairy science},
  year={2008},
  volume={91 12},
  pages={
          4466-76
        }
}
Improvement of the nutritional value of cow milk with transgenic expression of recombinant human alpha-lactalbumin (alpha-LA) has been previously attempted. However, the detailed characterization of the recombinant protein and analysis of the transgenic milk components are not explored yet. Here, we first report production of healthy transgenic cows by somatic cell nuclear transfer, in which expression of up to 1.55 g/L of recombinant human alpha-LA was achieved. The recombinant human alpha-LA… CONTINUE READING
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