Expression and characterization of bioactive human thrombopoietin in the milk of transgenic mice.

@article{Sohn1999ExpressionAC,
  title={Expression and characterization of bioactive human thrombopoietin in the milk of transgenic mice.},
  author={Bo Hwa Sohn and Soo Jin Kim and H N Park and Sang Kyu Park and Simon C. Lee and Hyo Jeong Hong and Yu Shin Park and Kenneth Ka-Ho Lee},
  journal={DNA and cell biology},
  year={1999},
  volume={18 11},
  pages={845-52}
}
Human thrombopoietin (hTPO) is the primary physiological regulator of platelet production and plays a pivotal role in promoting the proliferation and maturation of megakaryocytic progenitor cells and megakaryocytes. In this study, transgenic mice were produced harboring either full-length or the erythropoietin (EPO)-like amino-terminal domain of hTPO cDNA sequences fused to the regulatory elements of the bovine beta-casein gene. The transgene RNA was expressed exclusively in the mammary glands… CONTINUE READING