Expression and characterization of CD4-IgG2, a novel heterotetramer that neutralizes primary HIV type 1 isolates.

@article{Allaway1995ExpressionAC,
  title={Expression and characterization of CD4-IgG2, a novel heterotetramer that neutralizes primary HIV type 1 isolates.},
  author={Graham Allaway and Karen L Davis-Bruno and Gary A. Beaudry and Encarna B. G{\'o}mez Garc{\'i}a and Emily L Wong and Andrew M Ryder and Karl W. Hasel and M C Gauduin and Richard A. Koup and J. Steven McDougal},
  journal={AIDS research and human retroviruses},
  year={1995},
  volume={11 5},
  pages={533-9}
}
CD4-IgG2 is a novel fusion protein comprising human IgG2 in which the Fv portions of both heavy and light chains have been replaced by the V1 and V2 domains of human CD4. This tetrameric protein is being developed as an immunoprophylactic agent to reduce the probability of infection following HIV-1 exposure, in settings such as occupational or perinatal exposure to the virus. CD4-IgG2 has been expressed in Chinese hamster ovary cells and is secreted as a fully assembled heterotetramer. The… CONTINUE READING

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