Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease.

@article{Ying2008ExpressionAC,
  title={Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease.},
  author={Sun Ying and Brian J O'connor and Jonathan Ratoff and Qiu Meng and Cailong Fang and David Cousins and Guizhen Zhang and Shuyan Gu and Zhongli Gao and Betty W. H. Shamji and Matthew J. Edwards and Tak Hong Lee and Chris J. Corrigan},
  journal={Journal of immunology},
  year={2008},
  volume={181 4},
  pages={2790-8}
}
Asthma and chronic obstructive pulmonary disease (COPD) are associated with Th2 and Th1 differentiated T cells. The cytokine thymic stromal lymphopoietin (TSLP) promotes differentiation of Th2 T cells and secretion of chemokines which preferentially attract them. We hypothesized that there is distinct airways expression of TSLP and chemokines which preferentially attract Th1- and Th2-type T cells, and influx of T cells bearing their receptors in asthma and COPD. In situ hybridization… CONTINUE READING

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