Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy.

@article{Aronica2004ExpressionAC,
  title={Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy.},
  author={E. Aronica and Jan A. Gorter and Marja D. Ramkema and Sandra Redeker and Filiz Ozbaş-Gerçeker and Edwin A van Vliet and George L. Scheffer and Rik J. Scheper and Paul D. L. P. M. van der Valk and Johannes C. Baayen and Dirk Troost},
  journal={Epilepsia},
  year={2004},
  volume={45 5},
  pages={441-51}
}
PURPOSE This study investigated the cellular distribution of different multidrug resistance (MDR)-related proteins such as P-glycoprotein (P-gp), the multidrug resistance-associated proteins (MRP) 1 and 2, and the major vault protein (MVP) in normal and sclerotic hippocampus of patients with medically refractory mesial temporal lobe epilepsy (MTLE). METHODS Single- and double-label immunocytochemistry was used on brain sections of control hippocampus and of hippocampus of refractory MTLE… CONTINUE READING

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