Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex.

@article{Whisler1997ExpressionAC,
  title={Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex.},
  author={Ronald L. Whisler and Scott E Bagenstose and Y G Newhouse and Kathleen Carle},
  journal={Mechanisms of ageing and development},
  year={1997},
  volume={98 1},
  pages={57-73}
}
Optimal signal transduction through the T cell receptor (TCR)/CD3 complex requires the coordinated activities of protein tyrosine kinases (PTKs) Fyn and Lck in addition to protein tyrosine phosphatases (PTPases) such as CD45. Although T cells stimulated with anti-CD3 monoclonal antibodies (mAb) exhibit age-related reductions in tyrosine phosphorylations of cellular proteins, it is unknown if the reduction represent abnormalities in PTKs or PTPases. In the current studies, immune complex kinase… CONTINUE READING

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