Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons.

@article{Maggi2000ExpressionAB,
  title={Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons.},
  author={Mario Maggi and Tullio Barni and Guido Fantoni and Rosa Mancina and Cinzia Pupilli and Michaela Luconi and Clara Crescioli and Mario Serio and Gabriella Barbara Vannelli},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 4},
  pages={
          1658-65
        }
}
In a previous report, we demonstrated that in FNC-B4 cells, derived and characterized from a human fetal olfactory epithelium, both sex steroids and odorants regulate GnRH secretion. We now report the presence and biological activity of endothelin (ET)-1 in this GnRH-secreting neuronal cell. By in situ hybridization and immunohistochemistry, we found gene and protein expression of ET-1 and its converting enzyme ECE-1 in both fetal olfactory mucosa and FNC-B4 cells. The presence of authentic ET… CONTINUE READING
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