Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle.

@article{Sun2002ExpressionAB,
  title={Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle.},
  author={Xiaoyan Sun and David R Fischer and Timothy A. Pritts and Curtis J Wray and Per Olof Hasselgren},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2002},
  volume={282 2},
  pages={R509-18}
}
We examined the influence of sepsis, induced by cecal ligation and puncture in rats, on the protein and gene expression and hormone binding activity of the glucocorticoid receptor (GR) in skeletal muscle. Sepsis resulted in increased GR mRNA and protein levels and upregulated hormone binding activity in extensor digitorum longus and soleus muscles. Scatchard analysis suggested that the increased GR hormone binding activity reflected an increased number of hormone binding sites, whereas receptor… CONTINUE READING

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