Expression and assembly of a functional type IV secretion system elicit extracytoplasmic and cytoplasmic stress responses in Escherichia coli.

@article{Zahrl2006ExpressionAA,
  title={Expression and assembly of a functional type IV secretion system elicit extracytoplasmic and cytoplasmic stress responses in Escherichia coli.},
  author={Doris Zahrl and Maria Anna Wagner and Karin Bischof and Guenther Koraimann},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 18},
  pages={6611-21}
}
Conditions perturbing protein homeostasis are known to induce cellular stress responses in prokaryotes and eukaryotes. Here we show for the first time that expression and assembly of a functional type IV secretion (T4S) machinery elicit extracytoplasmic and cytoplasmic stress responses in Escherichia coli. After induction of T4S genes by a nutritional upshift and assembly of functional DNA transporters encoded by plasmid R1-16, host cells activated the CpxAR envelope stress signaling system, as… CONTINUE READING