Expression and amplification of the N-myc gene in primary retinoblastoma

@article{Lee1984ExpressionAA,
  title={Expression and amplification of the N-myc gene in primary retinoblastoma},
  author={Wen-Hwa Lee and A. Linn Murphree and William F. Benedict},
  journal={Nature},
  year={1984},
  volume={309},
  pages={458-460}
}
Retinoblastoma, the most common intraocular tumour of childhood, probably arises from embryonal cells and occurs in hereditary and non-hereditary forms1. Recent evidence suggests that this retinoblastoma (Rb) susceptibility gene located at chromosome 13q14 is actually recessive2–4. Knudson has proposed that the tumour is caused by two mutational events5. This idea was extended by Comings6, who suggested that dominantly inherited tumours may resuit from loss or inactivation of both alleles of… CONTINUE READING

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