Expression and amplification of HER-2/neu oncogene in uterine carcinosarcomas: a marker for potential molecularly targeted treatment?

@article{Raspollini2006ExpressionAA,
  title={Expression and amplification of HER-2/neu oncogene in uterine carcinosarcomas: a marker for potential molecularly targeted treatment?},
  author={Maria Rosaria Raspollini and Tommaso Susini and Gianni Amunni and Milena Paglierani and Francesca Castiglione and Francesca Garbini and Carmine Carriero and Gianfranco Scarselli and Gian Luigi Taddei},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2006},
  volume={16 1},
  pages={416-22}
}
Surgery is the treatment of choice for uterine carcinosarcomas; nevertheless, the poor effect of chemotherapy and radiotherapy represents an insidious problem for patients with metastatic or unresectable disease, and indeed, new therapeutic approaches are clearly required to improve survival of uterine carcinosarcoma patients. The HER-2 oncogene, located on chromosome 17, encodes for a tyrosine kinase growth factor receptor. We analyzed HER-2/neu overexpression by immunohistochemistry in 28… CONTINUE READING