Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues.

  title={Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues.},
  author={Michael A Reale and G Hu and A I Zafar and Robert H. Getzenberg and S M Levine and Eric R. Fearon},
  journal={Cancer research},
  volume={54 16},
The DCC (deleted in colorectal cancer) gene was identified because it is affected by somatic mutations in colorectal tumors, including allelic losses in greater than 70% of cancers and localized mutations in a subset of cases. The DCC gene also may be inactivated in other tumor types, including cancers of the pancreas, stomach, breast, prostate, and brain, as well as some leukemias. We have characterized DCC complementary DNAs obtained from human fetal brain tissues and IMR32 human… CONTINUE READING
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