Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas.


OBJECTIVES Recently, an allelic loss of phosphatase and tensin homologue (PTEN) was shown to occur in ameloblastomas. In carcinogenesis, loss of PTEN allows for overactivity of the phosphatidylinositol-3-kinase/protein kinase B (PI3K / AKT) pathway inducing an upregulation of mammalian-target of rapamycin (mTOR) and its downstream effector ribosomal-subunit… (More)
DOI: 10.1111/j.1601-0825.2007.01421.x