Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis.


BACKGROUND/AIMS Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver (NAFL) have a different prognosis and should be dealt with differently. The pathogenesis of NASH implicates the overexpression of cytochrome P450 2E1 (CYP2E1). We investigated whether the noninvasive determination of CYP2E1 activity could replace a liver biopsy in order to… (More)


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