Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils.

@article{Pouliot1998ExpressionAA,
  title={Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils.},
  author={Marc A. Pouliot and Caroline C. Gilbert and Pierre Borgeat and Patrice E. Poubelle and Sylvain Bourgoin and Christophe A Cr{\'e}minon and Jacques Maclouf and Shaun R McColl and Paul H. Naccache},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1998},
  volume={12 12},
  pages={
          1109-23
        }
}
Proinflammatory agents were assessed for their capacity to stimulate the expression of the inducible cyclooxygenase isoform (COX-2) in human neutrophils. A number of agents, including PMA, opsonized bacteria and zymosan, LPS, GM-CSF, TNF-alpha, and fMLP, induced COX-2 protein expression through signaling pathways involving transcription and protein synthesis events. Northern blots showed that freshly isolated neutrophils expressed low levels of COX-2 mRNA, which rapidly increased after… CONTINUE READING

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