Expression and activity of p-glycoprotein elevated by dexamethasone in cultured retinal pigment epithelium involve glucocorticoid receptor and pregnane X receptor.

@article{Zhang2012ExpressionAA,
  title={Expression and activity of p-glycoprotein elevated by dexamethasone in cultured retinal pigment epithelium involve glucocorticoid receptor and pregnane X receptor.},
  author={Yuehong Zhang and Min Lu and Xuerong Sun and Chunmei Li and Xielan Kuang and Xiangcai Ruan},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 7},
  pages={
          3508-15
        }
}
PURPOSE To investigate whether dexamethasone has an effect on functional expression of p-glycoprotein in cultured human RPE and, if so, whether this occurs through interaction with glucocorticoid receptor (GR) and pregnane X receptor (PXR). METHODS The human RPE D407 was treated with increasing concentrations of dexamethasone and/or RU486 for various time periods up to 24 hours. Treated cells were collected for cell viability, expressions of p-glycoprotein and PXR, and rhodamine 123… CONTINUE READING