Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

@article{Chaudhary1991ExpressionAA,
  title={Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells},
  author={P. M. Chaudhary and I. Roninson},
  journal={Cell},
  year={1991},
  volume={66},
  pages={85-94}
}
Hematopoietic stem cells show reduced staining with a mitochondrial fluorescent dye, rhodamine 123 (Rh-123), which was supposed to indicate decreased mitochondrial activity in these cells. Rh123 and several other fluorescent dyes are substrates for transport mediated by P-glycoprotein (P-gp), an efflux pump responsible for multidrug resistance in tumor cells. We have found that staining of human bone marrow cells with fluorescent dyes is potentiated by P-gp inhibitors and inversely correlated… Expand
P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.
Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.
Genetic basis of multidrug resistance of tumor cells
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
Resting and activated subsets of mouse multipotent hematopoietic stem cells.
  • G. Spangrude, G. Johnson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1990
Expression of a multidrug resistance gene in human cancers.
...
1
2
3
4
5
...