Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration.

@article{Loyer1994ExpressionAA,
  title={Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration.},
  author={Pascal Loyer and Denise Glaise and Sandrine Cariou and Georges Baffet and Laurent Meijer and Christiane Guguen-Guillouzo},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 4},
  pages={
          2491-500
        }
}
In normal adult liver, hepatocytes are arrested in G0, and they rapidly respond to a mass loss by a definite number of divisions. Thus, taking advantage of the in vivo regenerative capacity of the liver following partial hepatectomy, we have analyzed both expression and activation of p34cdc2 (= cdk1) and p33cdk2 through the cell cycle, particularly during the long lasting G1 phase and in the G1/S transition. While p33cdk2 is constantly expressed during the cell cycle, p34cdc2 is completely… CONTINUE READING

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