Expression and Processing of a Small Nucleolar RNA from the Epstein-Barr Virus Genome

  title={Expression and Processing of a Small Nucleolar RNA from the Epstein-Barr Virus Genome},
  author={Roland Hutzinger and Regina Feederle and Jan Mr{\'a}zek and Natalia Schiefermeier and Piotr J. Balwierz and Mihaela Zavolan and Norbert Polacek and H J Delecluse and Alexander H{\"u}ttenhofer},
  booktitle={PLoS pathogens},
Small nucleolar RNAs (snoRNAs) are localized within the nucleolus, a sub-nuclear compartment, in which they guide ribosomal or spliceosomal RNA modifications, respectively. Up until now, snoRNAs have only been identified in eukaryal and archaeal genomes, but are notably absent in bacteria. By screening B lymphocytes for expression of non-coding RNAs (ncRNAs) induced by the Epstein-Barr virus (EBV), we here report, for the first time, the identification of a snoRNA gene within a viral genome… CONTINUE READING
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