Expression and Molecular Characterization of Rat Renal d-Mannose Transport in Xenopus Oocytes

@article{Blasco2000ExpressionAM,
  title={Expression and Molecular Characterization of Rat Renal d-Mannose Transport in Xenopus Oocytes},
  author={Thomas A. Blasco and Jos{\'e} J. Aramayona and Ana Isabel Calvo Alcalde and Nabil Halaihel and Manuel E. Sarasa and V{\'i}ctor Sorribas},
  journal={The Journal of Membrane Biology},
  year={2000},
  volume={178},
  pages={127-135}
}
Abstract. Renal reabsorption appears to play a major role in d-mannose homeostasis. Here we show that in rat kidney, the transport of d-mannose by brush border membrane vesicles from tubular epithelial cells involves an uphill and rheogenic Na-dependent system, which is fully inhibited by d-mannose itself, incompletely inhibited by d-glucose, d-fructose, phloridzin, and phloretin, and noninhibited by l-mannose or disaccharides. In addition, this system exhibits both low capacity (112.9 ± 15.6… CONTINUE READING
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