Expression and Localization of the Calcium-Mobilizing Molecules , Calcineurin and NFAT in Germinal Center B Cells

Abstract

Intracellular signaling via the B-cell antigen receptor (BCR)regulates cellular dynamics in B cells, in a similar way to signaling via the T-cell receptor (TCR)in T lymphocytes. Cross-linking of BCR increases Ca influx as a first event,which then activates Ca -dependent signaling molecules. Calcineurin and nuclear factor of activated T cell(NFAT)are Ca… (More)

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