Expression and Localization of Estrogen Receptor‐β in Murine and Human Bone

@article{Vidal1999ExpressionAL,
  title={Expression and Localization of Estrogen Receptor‐$\beta$ in Murine and Human Bone},
  author={Olle Vidal and Lars Gunnar Kindblom and Claes Ohlsson},
  journal={Journal of Bone and Mineral Research},
  year={1999},
  volume={14}
}
Estrogens have profound effects on bone metabolism. Cellular responses to estrogens are mediated by estrogen receptors (ERs) which belong to the nuclear receptor superfamily. Two estrogen receptors, ERα and ERβ, have been cloned. Previously expression of ERα has been shown in osteoblasts. Here we demonstrate that the transcript for ERβ can be detected in the human osteosarcoma cell lines (MG‐63 and SaOS‐2) and in cultured human osteoblast‐like cells. We also show that ERβ protein is present in… 
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  • Biology
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2002
TLDR
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TLDR
The results indicate that the reduction of alveolar bone resorption is also related to a direct action of estrogen on osteoclasts, promoting apoptosis in these cells, via ERβ.
The role of estrogen receptor α in the regulation of bone and growth plate cartilage
TLDR
The newly characterized signaling pathways of estrogen, described in this review, provide a better understanding of the ERα signaling pathways, which may facilitate the design of new, bone-specific treatment strategies with minimal adverse effects.
The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone.
TLDR
The novel ER G PR30 is expressed in osteoblasts, osteocytes, and osteoclasts suggesting that non-genomic estrogen signaling via GPR30 may exist in bone, however, the functional role of GPR 30 in bone tissue remains to be elucidated.
Estrogen receptor specificity in the regulation of the skeleton in female mice.
TLDR
It is demonstrated that endogenous estrogens decrease the fat content in female mice via ERalpha and not ER beta, demonstrating that ER alpha and ER beta exert opposing effects in the regulation of longitudinal bone growth.
Studies of human osteoblasts in vitro: Estrogen actions and interactions with other hormones at different stages of differentiation
TLDR
A survey of the many studies reported reveals that the major action of estrogen in human osteoblasts in vitro is exerted through interactions with other hormones, cytokines, and growth factors.
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