Expression and Functional Activity of the Bitter Taste Receptors TAS2R1 and TAS2R38 in Human Keratinocytes

  title={Expression and Functional Activity of the Bitter Taste Receptors TAS2R1 and TAS2R38 in Human Keratinocytes},
  author={Ute W{\"o}lfle and Floriana A. Elsholz and Astrid Kersten and Birgit Haarhaus and W E M{\"u}ller and Christoph M Schempp},
  journal={Skin Pharmacology and Physiology},
  pages={137 - 146}
Recent studies have shown that human bitter taste receptors (TAS2Rs) are not only expressed in mucous epithelial cells of the tongue, but also in epithelial cells of the colon, stomach and upper respiratory tract. These cell types come in close contact with external bitter compounds by ingestion or breathing. In the present work we addressed the question whether bitter taste receptors might also be expressed in cornified epithelial cells of the skin. Here, we show for the first time the… 

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