Expression and DNA methylation status of microRNA-375 in patients with type 2 diabetes mellitus.

@article{Sun2014ExpressionAD,
  title={Expression and DNA methylation status of microRNA-375 in patients with type 2 diabetes mellitus.},
  author={Kan Sun and Xiangyun Chang and Liang Yin and Jun Li and Ting Zhou and Cheng Zhang and Xuan Chen},
  journal={Molecular medicine reports},
  year={2014},
  volume={9 3},
  pages={967-72}
}
Recent studies have shown that DNA methylation in the promoter of microRNA-375 (miR-375) downregulates its expression during tumorigenesis. However, it is not known if CpG methylation of the miR-375 promoter also has a role in the pathogenesis of type 2 diabetes mellitus (T2DM). In this study, the expression level and CpG methylation status of miR-375 in patients with T2DM were analyzed. Plasma samples from 100 patients with T2DM and 100 healthy controls with normal glucose tolerance (NGT) were… CONTINUE READING

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