Expression and Characterization of Hepatitis B Surface Antigen in Transgenic Potato Plants

@article{Shulga2004ExpressionAC,
  title={Expression and Characterization of Hepatitis B Surface Antigen in Transgenic Potato Plants},
  author={Nataliya Shulga and Elena B Rukavtsova and Mikhail A. Krymsky and V N Borisova and V. A. Melnikov and Victor A Bykov and Ya. I. Buryanov},
  journal={Biochemistry (Moscow)},
  year={2004},
  volume={69},
  pages={1158-1164}
}
Transgenic potato plants expressing the gene of hepatitis B surface antigen (HBsAg) under the control of the double promoter of 35S RNA of cauliflower mosaic virus (CaMV 35SS) and the promoter of patatin gene of potato tubers have been obtained. Biochemical analysis of the plants was performed. The amount of HBsAg in leaves, microtubers, and tubers of transgenic potatoes growing in vitro and in vivo was 0.005-0.035% of the total soluble protein. HBsAg content reached 1 μg/g in potato tubers and… CONTINUE READING

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