Expression and Biological Activity of Mouse Fibroblast Growth Factor-9 (*)

  title={Expression and Biological Activity of Mouse Fibroblast Growth Factor-9 (*)},
  author={Sylvia Santos-Ocampo and Jennifer S. Colvin and Arasu Chellaiah and David M. Ornitz},
  journal={The Journal of Biological Chemistry},
  pages={1726 - 1731}
Receptor specificity is an essential mechanism governing the activity of fibroblast growth factors (FGF). To begin to understand the developmental role of FGF-9/glial activating factor, we have cloned and sequenced the murine FGF-9 cDNA and expressed the protein in mammalian cells and in Escherichia coli. We demonstrate that the FGF-9 protein is highly conserved between mouse and human. Receptor specificity was determined by direct binding to soluble and cell surface forms of FGF receptor (FGFR… 

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