Expression and Activity of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-Isomerase in the Rat Purkinje Neuron during Neonatal Life.

@article{Ukena1999ExpressionAA,
  title={Expression and Activity of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-Isomerase in the Rat Purkinje Neuron during Neonatal Life.},
  author={Kazuyoshi Ukena and Chie Kohchi and Kazuyoshi Tsutsui},
  journal={Endocrinology},
  year={1999},
  volume={140 2},
  pages={805-813}
}
Recently, we demonstrated that cytochrome P450 side-chain cleavage enzyme (P450scc) occurs in the rat cerebellar Purkinje cell after differentiation and remains during neonatal development and into adulthood. 3b-Hydroxysteroid dehydrogenase/D-D-isomerase (3bHSD) is also an essential enzyme for progesterone biosynthesis not only in peripheral steroidogenic glands but also in the nervous system. In the present study, therefore, the expression of 3bHSD in the rat cerebellum was investigated during… CONTINUE READING