Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis

@inproceedings{Mameli2012ExpressionAA,
  title={Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis},
  author={Giuseppe Mameli and Luciana Poddighe and Alessandra Mei and Elena Uleri and Stefano Sotgiu and Caterina Serra and Roberto Manetti and Antonina Dolei},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Proposed co-factors triggering the pathogenesis of multiple sclerosis (MS) are the Epstein Barr virus (EBV), and the potentially neuropathogenic MSRV (MS-associated retrovirus) and syncytin-1, of the W family of human endogenous retroviruses. METHODOLOGY/PRINCIPAL FINDINGS In search of links, the expression of HERV-W/MSRV/syncytin-1, with/without exposure to EBV or to EBV glycoprotein350 (EBVgp350), was studied on peripheral blood mononuclear cells (PBMC) from healthy volunteers… CONTINUE READING
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