Expression analysis of some genes regulated by retinoic acid in controls and triadimefon-exposed embryos: is the amphibian Xenopus laevis a suitable model for gene-based comparative teratology?

@article{Renzo2011ExpressionAO,
  title={Expression analysis of some genes regulated by retinoic acid in controls and triadimefon-exposed embryos: is the amphibian Xenopus laevis a suitable model for gene-based comparative teratology?},
  author={Francesca Di Renzo and Federica Rossi and Renato Bacchetta and Mariangela Prati and Erminio Giavini and Elena Menegola},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2011},
  volume={92 3},
  pages={189-94}
}
BACKGROUND The use of nonmammal models in teratological studies is a matter of debate and seems to be justified if the embryotoxic mechanism involves conserved processes. Published data on mammals and Xenopus laevis suggest that azoles are teratogenic by altering the endogenous concentration of retinoic acid (RA). The expression of some genes (Shh, Ptch-1… CONTINUE READING