Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle.

@article{Morgan2002ExpressionAA,
  title={Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle.},
  author={David Morgan and Lorraine Eley and John A Sayer and Tom Strachan and Laura M Yates and A Scott Craighead and Judith A. Goodship},
  journal={Human molecular genetics},
  year={2002},
  volume={11 26},
  pages={3345-50}
}
Homozygous inv mice lack a functional inversin protein and exhibit situs inversus plus severe cystic changes in the kidney and pancreas. Although the inversin sequence has provided few clues to its function, we and others have previously identified calmodulin as a binding partner. We now provide evidence that inversin interacts with the anaphase promoting complex protein Apc2. As expected of an Apc2 target, inversin possesses D-boxes and site-directed mutagenesis of the well-conserved D-box… CONTINUE READING

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